Stretch-activated cation channels in human fibroblasts
نویسندگان
چکیده
منابع مشابه
Visualization of Ca2+ entry through single stretch-activated cation channels.
Stretch-activated channels (SACs) have been found in smooth muscle and are thought to be involved in myogenic responses. Although SACs have been shown to be Ca(2+) permeable when Ca(2+) is the only charge carrier, it has not been clearly demonstrated that significant Ca(2+) passes through SACs in physiological solutions. By imaging at high temporal and spatial resolution the single-channel Ca(2...
متن کاملCa2+ influx through stretch-activated cation channels activates maxi K+ channels in porcine endocardial endothelium.
The endocardial endothelium is an important modulator of myocardial function. The present study demonstrates the existence of a stretch-activated Ca(2+)-permeable cation channel and of a Ca(2+)-activated K+ channel in the endocardial endothelium of the porcine right atrium. The stretch-activated channel is permeable for K+, Na+, Ca2+, and Ba2+, with mean conductances of approximately 32 pS for ...
متن کاملStretch-activated channels in human retinal Muller cells.
The cell-attached and excised patch configurations of the patch clamp technique were used to study stretch-activated ion channels in Muller glial cells that were obtained from postmortem adult human retinas and were maintained in culture. A stretch-activated channel permeable to monovalent and divalent cations was found. Ion channels of this type have not been demonstrated previously in glial c...
متن کاملStretch activated ion channels in ventricular myocytes.
Patch-clamp recordings from ventricular myocytes of neonatal rats identified ionic channels that open in response to membrane stretch caused by negative pressures (1 to 6 cm Hg) in the electrode. The stretch response, consisting of markedly increased channel opening frequency, was maintained, with some variability, during long (greater than 40 seconds) stretch applications. The channels have a ...
متن کاملStretch-activated cation channels in skeletal muscle myotubes from sarcoglycan-deficient hamsters.
Deficiency of delta-sarcoglycan (delta-SG), a component of the dystrophin-glycoprotein complex, causes cardiomyopathy and skeletal muscle dystrophy in Bio14.6 hamsters. Using cultured myotubes prepared from skeletal muscle of normal and Bio14.6 hamsters (J2N-k strain), we investigated the possibility that the delta-SG deficiency may lead to alterations in ionic conductances, which may ultimatel...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1988
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(88)82944-8